She is more transformed than Omigran

French researchers have identified a new variant of the SARS-CoV-2 corona virus in a dozen patients. It has 46 mutations and 37 deletions more than Omicron.

SARS – CoV – 2 Corona virus virus particles in human cells. Credit: NIAID

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In the south France Something new was discovered VariationSuper changed“In Corona virus SARS-CoV-2, Its code name in the International Genetic Database GISAID There is P.1.640.2 (Inheritance of Bangol). Scientists who saw this decided to name it IHU, But not part of it yet Variations in the investigation World Health Organization (WHO) This does not mean that it cannot become new in the future Variation of anxiety Such asAlpha, Beta, gamma, the Delta And this OmigronHowever, at the moment there is still more data to find out what it really is Transmissible, Rude And / or can be avoided Neutralizing antibodies, And induced Govit vaccine Than related to the former Natural infection. It does not exhibit significant diffusion potential because it is currently reported in only a dozen cases in France, all of which are related Patient Zero Comes from Cameron.

The discovery of a new variant of the SARS-CoV-2 corona virus was a French research team led by scientists at IHU Méditerranée Infection, who worked closely with colleagues at Aix-Méditerranée Médicale SYNLAB University. INSERM Company. Scientists, led by Professor Philip Coulson, a professor at the Institute for Research in Lee Development (IRT) at the University of Marseille, have identified it by submitting a biological model of a Cameroonian traveler. Genetic sequence The latest generation “Oxford Nanopore Technologies”. The new variant B.1.640.2 is more modified than Omicron, revealing the main cause of the current infections. They have actually been found 46 mutations e 37 deletions, With 30 amino acid substitutes and 12 removals. Of those, 14 are amino acid substitutes and 9 are derivatives Proteina s The Spike, SARS-CoV-2 corona virus-exploited biologic lochip binds to human cells, breaks down cell wall, pours viral RNA into it, and initiates Response, Disease-causing mechanism (call COVID-19) Strain is the “relative” of the old variant P.1.640.1, Which differs by 25 nucleotide substitutes and 33 deletions.

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Among the most important amino acid substitutes for “IHU” discovered by Professor Coulson and colleagues N501Y And this E484K, Both are types of anxiety. First, associated with what was identified in the alpha (formerly English B.1.1.7) More infection, From the second to the first Reduced sensitivity Antibodies induced by vaccines. Just because it contains both B.1.640.2 or “IHU” does not automatically mean that it is highly contagious and elusive because combinations of mutations can “cancel themselves” or be in any condition Not very positive To pathogen. It is certainly a remarkable fact that at this time it has only been diagnosed in a few patients, considering that the first case was reported about a month ago. However, further studies are needed to determine all the characteristics of the variant and the potential threats; Only then will the World Health Organization (WHO) decide whether or not to put it in the magnifying glass. After all, there are thousands of generations of SARS-CoV-2 corona virus, but in most cases The set of mutations was not significant And it does not bring specific “benefits” to the pathogen. Details of the new variant are described in the article “A new SARS-CoV-2 variant of Cameroonian descent that modifies both N501Y and E484K in spike protein has emerged in southern France.”Uploaded on MedrXiv and published in the pending peer review and science journal.

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